A possible role of intracellular Ca2+ in the regulation of the ACh receptor-ion channel complex of the sympathetic ganglion cell.
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概要
- 論文の詳細を見る
Effects of caffeine (2-6 mM) on the nicotinic transmission of the bullfrog sympathetic ganglion was studied by using an intracellular recording technique. Caffeine (2-4 mM) decreased the amplitude, quantal content and quantal size of the fast e. p. s. p. and the amplitude of ACh potential. Under these conditions, resting membrane potential was almost unchanged with a slight decrease in the membrane resistance. Injection of "EGTA" increased the amplitude of the fast e. p. s. p. under the effect of caffeine (6 mM). These results suggest that caffeine suppresses the nicotinic transmission of the bullfrog sympathetic ganglion by both the pre- and postsynaptic actions and that a considerable portion of the postsynaptic action was the result of a rise in the intracellular free Ca<SUP>2+</SUP> concentration.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kuba Kenji
Department Of Physiology Nagoya University Graduate School Of Medicine
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Morita Kiichiro
Department Of Neuropsychiatry Kurume University School Of Medicine
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Kato Eiji
Department Of General Education Kobe University Of Mercentile Marine
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MORITA KIICHIRO
Department of Physiology, Kurume University School of Medicine
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- A possible role of intracellular Ca2+ in the regulation of the ACh receptor-ion channel complex of the sympathetic ganglion cell.