HYGIENIC INVESTIGATION ON WORKERS DEALING WITH PENTACHLOROPHENOL (PCP) IN A RUBBER MANUFACTURING INDUSTRY

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A) Comparison among the working plants1) Between the female P- and C- group: Taking only that which showed a significant difference numerically in tests, the authors found the hemoglobin content of the P-group to be a little smaller, which was attributed to the inclusion of three patients with anemia. Omitting what was possible to eliminate, we found the difference to be not significant. Blood sugar was significantly higher in the P-group on a 95% confidence limit (t=2.086). Maximum blood pressure was significantly lower in the P-group (t=2.56). In the other matters differences were not significant. In the urinary test, urobilinogen tended to be highly positive in the P-group, red blood cell excretion in the sediment was almost similar in both the P- and C- groups, and PCP was not excreted in urine in the C-group.2) Among the Brushing (A) in both the P- and C- groups: Maximum blood pressure was significantly lower in the former (t=3.24).3) Between the Brushing (A) and (B) in the P-group: Hemoglobin content and neutrophile leucocytes were lower in (B) (t=2.74 and 2.75), blood sugar higher in (B) (t=2.54), blood pressure lower in (A) (t=2.22) and blood sedimentation rate was higher in (A) (t=2.86).4) Among the Brushing (B) in both the P- and C- groups: In the former, hemoglobin content was lower (t=2.99), blood sugar higher (t=2.94) and blood sedimentation rate lower (t=3.28).5) Between (A) and (B) in the C-group: In the former red and white blood cell counts were lower (t=2.55 and 2.17).B) Variations of the examination values in April, May and June in each plant.In order to reveal whether the symptoms resulting from the absorption of PCP might appear with the lapse of time or not, monthly variations were tested statistically. In all plants there were remarkable variations in blood pressure. There was significant difference because of the decreasing value in June. As the moment some reasons are given which might explain this decrease. First, one of the examiners was obliged to be exchanged on account of an accident in June. Second most of the workers were tested for blood pressure for the first time; therefore, because of the mental tension involved from such initial tests, the values in April and May might have been higher. Moreover, the test was done inevitablly in noisy circumstances in the factory, because the work was very busy that month, so that vessel sounds were hardly ausculated . In any case these monthly variations of the blood pressure were observed in both the P- and C- groups, consequently they would not depend upon the PCP.In the Brushing (B) of the C-group, the hemoglobin content increased in June; accordingly a significant difference was shown, but its factor is uncertain.C) Comparison with the normal valuesHemoglobin contents and erythrocytes showed a little decrease in both the P- and C-groups. Especially hemoglobin contents of the P-group in the Brushing (B) were at low levels. This was because two patients with anemia were included ten workers, and they could not be eliminated. One of them had been treated diagnostically f or anemia before coming in contact with PCP, but the anamnesis of the other is uncertain .Urinary urobilinogen was moderately positive at 23.8% in the P-group and 15.66% in the C-group, and there were not great differences among the plants.Positive levels over 5% in 30 minutes by the BSP-test were very few.Red blood cells in the urinary sediment were excreted at almost the same to, 56.3% in the female P-group and 53.2% in the female C, and there was no differences among those plants. In 3 of 8 samples in the male C-group, the excretion of the cells were also observed.Detection of the PCP in urine showed that the PCP was absorbed slightly in the body following the contact of the rubber cement containing PCP with the fingers. But it is not yet determined how much excretion of the PCP in urine is toxic.Deichmann et al. administered perorally 25 to 50 mg of PC
久留米大学医学部 The Kurume Medical Journal 編集部の論文

HYGIENIC INVESTIGATION ON WORKERS DEALING WITH PENTACHLOROPHENOL (PCP) IN A RUBBER MANUFACTURING INDUSTRY

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