EXPERIMENTAL STUDIES ON THE TOXICITY OF BENZENE HEXACHLORIDE (BHC) AND DICHLORODIPHENYLTRICHLOROETHANE (DDT):III. HISTOPATHOLOGICAL STUDY
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The histopathological findings about the administrations of gamma-BHC and BHC-mixture are almost the same, and no differences of disorders in each administrations were observed.In the lungs, the congestion of blood vessels was clear, and hemorrhage, atelektasis, or catarrhal pneumonia were observed. These disorders were the same ones, as shown in the second report (2), in the dust inhalation tests of BHC and DDT powders. In the inhation test, it was not completely denied that these were caused merely by the mechanical obstacle of dust. The tests of toxicity by administering only fat or oil solution containing these two compoundss howed the same results. Therefore the above-mentioned pulmonary disorders can be inferred to be caused by BHC compound.In the liver, the cells of the middle part of the lobule were swollen and became transparent, the middle parts were infiltrated by fat and the peripheral parts had degenerated with fatty or fine vacuolation. It was evident that these were the toxic disorders of the liver.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
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