Evaluation of the Intramembrane Particle Count in Biopsied Myocardium from Patients with Idiopathic Cardiomyopathy.
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the abnormalities of myocardial membrane structure in cardiomyopathy, the density of intramembranous particles (IMP) of mitochondria, sarcoplasmic reticulum and sarcolemma, and the number of caveolar necks was evaluated by freeze-fracture morphology. The subjects consisted of 17 patients with hypertrophic cardiomyopathy (HCM), 6 patients with dilated cardiomyopathy (DCM), and 7 patients as controls. The results showed that the numbers of IMPs on the membrane faces of mitochondria, sarcoplasmic reticulum and sarcolemma were significantly decreased in HCM and DCM, and that they were decreased more markedly in DCM than in HCM. The number of caveolar necks was significantly decreased in DCM. Thus, the decreased numbers of IMPs on myocardial membranes and the decrease in caveolar necks may be important characteristics resulting from abnormal myocardial membrane metabolism in cardiomyopathies, HCM and DCM.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
Adachi Kyo
Institute of Cardiovascular Diseases, Kurume University School of Medicine
-
Toshima Hironori
Department Of Cardiology Kurume University Medical Center
-
YAMASHITA YOSHINAO
Department of Internal Medicine, Kurume University School of Medicine
-
YAMASHITA YOSHINAO
Department of Medicine, Kurume University School of Medicine
-
NOZUHARA AKIRA
Institute of Cardiovascular Diseases, Kurume University School of Medicine
-
SUGIU YUJI
Department of Medicine, Kurume University School of Medicine
関連論文
- DETECTION OF CATECHOLAMINE-INDUCED DNA SINGLE STRAND BREAKS BY THE ALKALINE ELUTION METHOD
- -0058-MULTIPLE MITOCHONDRIAL DNA DELETIONS IN CARDIOMYOPATHY
- Natural History of Hypertrophic Cardiomyopathy: Japanese Experience
- Changes of Ventricular Monophasic Action Potential Duration by Stellate Ganglion Stimulation in Dogs
- 12)PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS IN PATIENTS WITH IDIOPATHIC CARDIOMYOPATHY : THE 7th CONFERENCE ON CARDIOMYOPATHY
- Natural and unnatural histories of the pulmonary vascular circulation with a ventricular septal defect (VSD)
- Right ventricular ejection fraction assessed by digital subtraction angiography using videodensitometric analysis.
- The mechanical cardiac cycle. Shortening time of the internal diameter of the canine left ventricle.:Shortening Time of the Internal Diameter of the Canine Left Ventricle
- Usefulness and Limitations of Left Ventricular End-Systolic Indices, End-Systolie Volume and Left Ventricular Peak Systolic Pressure/End-Systolic Volume Ratio
- Changes in the prevalence of hypertension and obesity in a rural area of Japan.
- Comparison of organic acids in three parts of the human heart by gas chromatography-mass spectrometry.
- CLINICAL APPLICATION OF THERMOGRAPHY TO PATIENTS WITH VIBRATION DISEASE
- Computer videodensitometry of digital subtraction angiography for measurement of the cardiac volume.
- Forskolin actions on transient potassium current of rat ventricular cardiomyocytes.
- Alterations in Beta-Adrenergic Receptor Density and Cyclic-AMP Level in the Myocardium of Rats Chronically Treated with Alcohol.
- Evaluation of the Intramembrane Particle Count in Biopsied Myocardium from Patients with Idiopathic Cardiomyopathy.
- Clinical manifestations of acute Coxsackie-B viral myocarditis and pericarditis with a special reference to serum enzyme patterns and long-term prognosis.