CLINICAL STUDIES ON ATP (ADENOSINE TRIPHOSPHATE):REPORT 2. THE EFFECT OF ATP ON THE LIPID METABOLISM IN DIABETIC PATIENTS

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In diabetic patients, the effect of ATP injection on the lipid metabolism was compared with insulin action. The effect of administrating both ATP and Vitamin B1 in diabetic patients, and the effect of administrating ATP alone in hepatic patients were also studied. The results were summarized as follows. 1) Fatty acid and total cholesterol in blood plasma of diabetic patients were relatively increased in many cases, however these showed no correlation to fasting blood sugar levels. 2) Fatty acid and total cholesterol tended to decrease and the proportion of cholesterol ester tended to increase by administration of ATP similarly as were observed by insulin injection. 3) The blood levels of pyruvic acid, of fatty acid and of total cholesterol, and the proportion of cholesterol ester showed no remarkable changes by injection of Vitamin B1 alone. However by injecting Vitamin Bi with ATP, pyruvic acid, fatty acid and total cholesterol were decreased, and the proportion of cholesterol ester tended to increase. 4) When ATP was injected in hepatic patients, blood levels of pyruvic acid, of fatty acid and of total cholesterol, and the proportion of cholesterol ester showed no remarkable changes.
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