CLINICAL STUDIES ON ATP (ADENOSINE TRIPHOSPHATE):REPORT 1. THE EFFECT OF ATP ON THE CARBOHYDRATE METABOLISM IN DIABETIC PATIENTS

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In diabetic patients (41 adults), the effect of ATP injection on the carbohydrate metabolism was compared with insulin action. The results were summarized as follows. 1) By administration of ATP, blood sugar levels in diabetic patients were usually reduced, but these levels in normal subjects were unchanged by ATP administration. 2) In many cases, alimentary hyperglycemia in diabetic patients was controlled by administration of ATP, and hypoglycemic effect of insulin was raised when ATP was injected with insulin. 3) Serum inorganic phosphorus were reduced by administration of ATP and the reducing-ratio of phosphorus by intravenous injection of glucose was intensified by administration of ATP. 4) Blood pyruvic acid levels were raised by insulin injection. On the contrary, blood pyrubic acid levels were reduced by ATP injection, and the elevation of blood pyruvic acid levels by intravenous injection of glucose was also controlled by ATP injection. 5) Blood lactic acid levels were reduced by ATP injection and the elevation of lactic acid levels by intravenous injection of glucose was controlled by ATP.
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