血清抗ヒアルロニダーゼ因子に關する研究
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Serum hyaluronidase inhibitor activity (HDI) was determined by turbidimetric method in this experiment.1) The existence of HDI in normal human subjects was recognized, and there is no difference in HDI value between man and woman.2) HDI increased in both liver and kidney disease. HDI value has a certain interdependence with liver function in liver disease, and with proteinuria, urine volume, hematuria, blood pressure, plasma protein electrophoretic pattern, and edema etc. in kidney disease. That is, HDI value has a relationship with the severity of disease clearly.3) In the rabbits with experimentally injured kidney HDI increased day after day, and the increase of HDI kept pace with the severity of the disease.4) HDI increased by the administration of both cortisone and ACTH, but do not increase or decrease by DOCA, increased by adrenalin. Moreover, in nephrotic syndrome accompanied with the clear increase of HDI, effective cases in ACTH, Prednisolone treatment had the normalization of HDI value. Therefore, it is supposed that HDI value is regulated by pituitary-adrenocortical system.5) In whole body X-ray irradiated rats, HDI value increased at 48 hrs after irradiation.6) Sulfhydryl reagents (ferricyan, PCMB, IAc) inhibited the hyaluronidase activity in vitro, recovered by addition of L-cysteine into the system. Moreover, normal serum and nephrotic serum inhibited the hyaluronidase activity, recovered by addition of L-cysteine, According to this fact, a close relationship between HD, HDI and SH-radical was suggested.
- 社団法人 日本内科学会の論文
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