コバルトの貧血に及ぼす実験的ならびに臨床的研究-2-

概要

論文の詳細を見る
Experiment was carried out to explain the mechanism of cobalt polycythemia by using the bone marrow cell culture of the rabbit at 37 degree C.By adding ccbaltous chloride to the bone marrow culture, no direct increase of the erythrocytes, reticulocytes, and hemoglobin concentration was observed, however by the formation of methemoglobin in the hemoglobin of the bone marrow cell, an action takes place to inactivate the hemoglobin. This action is due to interference of the enzymatic reduction system of the bone marrow cell, impeding the transport of oxygen, resulting in anoxia of the bone marrow.Hematopoietic effect of cobalt is due chiefly to tissue anoxia of the organ. This was observed from its distribution in the body after administration of cobalt. On the other hand anoxia of the bone marrow cell and peripheral blood is also considered to be a contributive factor.In vitro the methemoglobin formation of cobalt was observed as same as in rabbit in non-responsive patients to cobalt, however, clinically the cobalt had no effect to these patients due to the lack of hematopoietic ability.
社団法人日本内科学会の論文