STUDIES ON THE LEUCOCYTE-INCREASING-SUBSTANCES:(3) LEUCOCYTE MOBILIZING ACTION OF CYSTEINE ON THE RABBITS WITH THE LIVER INJURED BY CCL4 AND THOSE WITH THE CERVICAL CORD SEVERED

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Cysteine administered to normal rabbits showed a remarkable effect on leucocyte count with its two characteristic peaks in the increasing phase the first peak appeared three to four hours after the administration of cysteine, and the other six to eight hours after it.For the purpose of finding out by what mechanism the above peaks were formed, cysteine was administered to the rabbits with the cervical cord severed and those with the liver injured by CCl4, and the leucocyte increasing effect upon them was investigated as in the first report. The results obtained are as follows:1. In the rabbits with the cervical cord severed the second leucocytosis did not appear and only the first one was observed.2. In the rabbits with the liver injured by CCl4 just about the same leucocyte increasing effect was revealed as in the normal rabbits with two characteristic peaks of leucocytosis. Especially the first peak was remarkably proved in all cases.3. Taking into consideration the results from the two experiments, it can be recognized that cysteine exerts both peripheral (working directly on the bone marrow) and indirect central action controlled by the central nervous system-the first peak being caused by the peripheral and the second by the central action.
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