Multicentric & hypovascular hepatocellular carcinoma and its relationship to pathological findings.

概要

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We resected 4 cases of multicentric hepatocellular carcinoma (HCC) with cirrhosis. Typical trabecular type HCC were seen in two of cases. At least one of the lesions in all cases has hypovascular tumors by selective hepatic angiography. Accumulation of hepatocytes with high N/C ratio and hyperchromatic nuclei commonly formed in 2 or 3 cell plates, and partially in trabecular pattern. Because of the lack of space, we witnessed hardly any so-called "blood space" in the fields, which leads us to believe that it is hypovascular by angiography. No tumor thrombi were evident. Furthermore, tumor characteristics were different in all cases. Therefore we diagnosed these cases to be multicentric hepatocellular carcinomas.
社団法人日本肝臓学会の論文