Experimental studies on Extrahepatic Portal Obstruction.

概要

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A model of Extrahepatic Portal Obstruction was prepared with the rat and the effect of portal vein ligation (PVL) on liver functions and the formation of hepato-petal collaterals were investigated using the mitochondrial function of the liver, hepatic blood flow, portal pressure and portography.<BR>Hepatic blood flow (HBF) significantly decreased until 5 days after PVL, however, due to the formation of hepato-petal collaterals, HBF gradually increased and reached the normal value at 3 weeks after PVL. Respiratory parameters of mitochondria, such as RC, S3, ATP synthesis, gradually decreased and reached the lowest level at 5 days after PVL, while they recovered to the normal value in accordance with the increasing HBF at 3 weeks after PVL.<BR>In Extrahepatic Portal Obstruction, although the liver is temporarily deteriorated by portal vein obstruction such as portal vein thrombosis, HBF and the liver function is to be maintained normally with the formation of hepato-petal collaterals.
社団法人日本肝臓学会の論文