Evaluation of interleukin 1 production of peripheral monocytes in cases with persistent hepatitis B virus infection.

概要

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In order to evaluate the function of macrophages as an immunomodurator, the interleukin 1 (IL 1) production of peripheral monocytes was studied in cases with persistant hepatitis B virus infection.<BR>The subjects in this study were nineteen healthy controls without HBV infection and thirtysix patients with persistent HBV infection; nine cases with asymptomatic HBV carrier (AsC), nine cases with chronic inactive hepatitis (CIH), eleven cases with chronic active hepatitis (CAH) and seven cases with liver cirrhosis (LC).<BR>The interleukin 1 production in AsC was significantly higher than those in control, CIH and CAH. On the other hand, there were no significant differences in IL 1 production between control, CIH, CAH and LC.<BR>Furthermore, IL 1 production of peripheral monocytes was not correlated with histological findings of the liver, HBV related markers and liver function tests.<BR>From these results, it is suggested that the activated function of macrophage in the IL 1 production may play a primary role in the pathogenesis of asymptomatic carrier state.