THE STUDY ON ENDOCRINE EXOPHTHALMOS AN EXOPHTHALMOS-PRODUCING REACTION (EPR) BY THE SERUM OF PATIENTS SUFFERING FROM THYROID DYSFUNCTION

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概要

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• 1) Gold fish received injection of sera from several patients with orbital tumor and acromegaly and normal persons did not become exophthalmic.2) The relationship between thyroid function in patient and exophthalmos-producing reaction in fish. When exophthalmos-producing reaction is positive the patient may be hyperthyroid or hypothyroid but is usually euthyroid. Similarly, when endocrine exophthalmos follows thyroidectomy or 1-131 therapy, the patinent may show evidence of thyrotoxicosis or of myxedema but usually has normal thyroid function.3) The relationship between exophthalmos in patient and exophthalmos-producing reaction in fish.a) Exophthalmos-producing reaction was generally negative in the pa-tients with hyperthyroid without exophthalmos.b) Exophthalmos-producing substance may be temporarily increased in the early or progressive stage of exophthalmos with thyrotoxicosis, but exophthalmos-producing reaction was almost negative in the sta-tionary stage.c) In long-standing exophthalmos, fish received injections of sera did not only exophthalmic, but observed marked decrease of intercorneal distance. The author supposed that there are anti-EPS substance in such a patient serum.d) There are a rough correlation between the degree of the exophthalmos in the patient and the degree of reaction in the fish.4) The roentgen therapy to pituitary region were effective in cases with positive serum, while the cases with negative serum were unresponsive to the therapy. The author believed that exophthalmos-producing reaction was a very important factor in determination of the methods of treatment for exophthalmos.

• The Keio Journal of Medicineの論文

著者

• Uemura Y.

  Department of Physics, Univ. of Tokyo

• UEMURA YASUO

  Department of Ophthalmology, School of Medicine, Keio University

• Uemura Y.

  Department of Physics, Chuo University

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