SERUM CHOLESTEROL LEVEL OF VISCOSE RAYON WORKERS

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概要

• 論文の詳細を見る

• The level of serum total and esterified cholesterol was estimated and the ratio of esterified to total cholesterol was calculated in the total of 134 CS2 workers and 48 controls in four representative viscose rayon plants in a rural district of Japan. The four plants were grouped into two categories according to CS2 concentration in the air of working places: the A group consisted of two plants where CS2 concentration was ranging from 5 to 19 ppm and the number of subjects was 64, and the B group comprised two plants where CS2 concentration was from 15 to 65 ppm and 70 subjects were selected randomly.In the A group the average values of total cholesterol, esterified cholesterol and ratio of esterified to total cholesterol in the serum were 157.5 mg percent, 95.0 mg percent and 60.4 percent, respectively. There was no statistical sig-nificant difference between these average values in the CS2 exposed workers and the controls, whose total cholesterol, esterified cholesterol and ester ratio were measured as 154.0 mg percent, 96.1 mg percent and 62.2 percent re-spectively.In the B group the average values of total cholesterol, esterified cholesterol and ester ratio were 212.6 mg percent, 111.4 mg percent and 52.8 percent respectively. The significant differences were ascertained statistically in total cholesterol, esterified cholesterol and ratio of esterified to total cholesterol of the CS2 workers from the controls. The serum total and esterified cholesterol appeared to be higher and the ester ratio was lower in the subjects of the B group which was exposed to a relatively high concentration of CS2 than in the A group which was exposed to a lower concentration. Among 70 subjects of the B group, 12 persons had a slight headache, 5 fatigue during their shift, 6 irritability, 8 impaired appetite, 10 sleeplessness and 5 pains in legs.The blood change of the same type was assured by an experiment of rabbits which were exposed to 150 to 180 ppm of CS, for 200 days.We would like to conclude that the change of the serum cholesterol level can be taken for one of the early signs of chronic CS2 poisoning.

• The Keio Journal of Medicineの論文

著者

• Sakurai Tsutomu

  Department Of Chemistry And Fuel Research Japan Atomic Energy Research Institute

• SAKURAI TSUTOMU

  Department of Preventive Medicine and Public Health School of Medicine, Keio University

• HARASHIMA SUSUMU

  Department of Preventive Medicine and Public Health School of Medicine, Keio University

• TOYAMA TOSHIO

  Department of Preventive Medicine and Public Health School of Medicine, Keio University

• HARASHIMA SUSUMU

  Department of Preventiue Medicine & Public Health, School of Medicine, Keio University

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