Clinical evaluation of serum AFP change before and after TAE in hepatocellular carcinoma.

概要

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The effect of TAE (Transarterial embolization) on the tumor growth rates was studied in 26 patients with hepatocellular carcinoma (RCC) whose AFP levels were over 400 ng/ml before TAE. The growth rate in each case was expressed as the doubling time of serum AFP level (T<SUB>2</SUB>AFP) and classified into three growth types; rapid≤60 days, 60<intermediate≤120 days, 120 days<slow: and compared them before and after TAE in each of them.<BR>The results were the followings: (1) After the first TAE, the growth rate became more rapid in 12 cases (46.2%), and it became slower in 6 cases (23.1%). (2) The survival time was depended upon the T2AFP following TAE, but not upon the growth rate before TAE, particularly the prognosis in the rapid growth type after TAE was poorer than that of intermediate or slow growth type. (3) It seemed to be effective and necessary to give additional theraoy during AFP reduction period after TAE. (4) It was suggested that the biological characteristics of HCC might be changed by the first TAE, thus it is important to have strict indication of the therapeutic modality in the cases with slow or intermediate growth rate.