An immunohistopathological study on peptide hormone-laden tumor cells in biliary cystadenocarcinoma.

概要

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Three cases of biliary cystadenocarcinoma were submitted for study of peptide hormone-laden tumor cells by immunohistochemical procedures. Argyrophil and argentaffine cells were identified in these tumor tissues. The enterochromaffine tumor cells were studied by immunohistochemical methods to identify the localization and function of tumor cell. Gastrin, serotonin and calcitonin were positive in tumor cells of these three cases of biliary cystadenocarcinoma. These findings suggested that biliary cystadenocarcinoma has a strong resembrance to borderline malignant epithelial neoplasm such as mucinous cystadenocarcinoma of ovary and pancreas. From a prognostic viewpoint, it is very important for diagnosis of biliary cystadenocarcinoma whether tumor tissue contains peptide hormone-laden tumor cells or not.
社団法人日本肝臓学会の論文