多変量解析による慢性肝疾患重症度の術前予備

概要

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A mutivariate analysis was employed on 136 hepatectomized patients with hepatocellular carcinoma to distinguish the histopathologic severity of chronic liver disorders and to evaluate the degree of liver fibrosis, Platelet count, total protein, prothrombin time, and liver volume/weight ratio were the parameters selected for the discrimination between chronic hepatitis and type B' liver cirrhosis, while ICG retention rate, spleen volume, ICGRmax, linearity index, and partial thromboplastin time were those for the discrimination between type B' and type B liver cirrhosis. Discrimination based on the discriminant score was statistically significant. In addition, a multiple regression demonstrated that the degree of liver fibrosis was predictable by mainly ICG plasma disappearance rate and thymol turbidity tests. In conclusion, histopathologic severity of chronic liver disease can be estimated based on the discriminant scores and multiple regression formula prior to surgery.
社団法人日本肝臓学会の論文