Prognosis after hepatic resection in patients with hepatocellular carcinoma on the bases of the morphometry and gross classification.

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Micromorphometric values in 84 cases of hepatocellular carcinoma (HCC) treated by hepatectomy were studied using image analyzer. The survival rates in cases with coefficient of variance of nuclear form factor (NCV) less than 5.5% were significantly low. In cases with cell area more than 150μmμm2 or nucleo-cytoplasmic area ratio (N/C) less than 0.28, vascular invasion was less frequent. In those with NCV less than 5.5%, intrahepatic metastases were less frequent. In stage III, the survival rates in cases with N/C less than 0.28 or NCV less than 5.5% were significantly high. Among the cases treated by relative curative hepatectomy, intrahepatic metastases were less frequent in cases with N/C less than 0.28. After relative non-curative hepatectomy, the survival rates in cases with N/C less than 0.28, in which vascular invasion was less frequent, were significantly high. These results indicate that N/C and NCV may be useful as a prognostic factors.
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