門脈圧亢進の程度と肝の組織学的変化との関係に関する基礎的研究

概要

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To clarify the factor for determination of the level of portal vein pressure in liver cirrhosis, the livers of the normal rats and the cirrhosis rats induced by carbon tetrachloride were isolated and perfused with Krebs-Ringer bicarbonate buffer solution, and were then fixed with formalin at various perfusion pressures. Portal vein pressures in vivo in the normal, the mild and the severe cirrhosis ratswere good agreement with the perfusion pressures at the minimum hepatic vascular resistance (MHVR) in correcting in terms of blood of Hct. 40%. The normal and the mild cirrhotic liver fixed at the perfusion pressure given the MHVR showed the maximum dilatation of the hepatic vascular tree (mainly the sinusoids) within the physiological range. Moreover, the dilatation of hepatic vascular tree related closely to an increase in liver volume. On the other hand, in the severe liver cirrhosis, neither the volume of hepatic vascular tree nor the liver volume was correlated significantly with the changes in perfusion pressure. This is thought that severe proliferation of connective tissue restricts the increase in liver volume and the dilatation of hepatic vascular tree.
社団法人日本肝臓学会の論文