肝疾患におけるantibody-dependent cell-mediated cytotoxicity(ADCC)に関する研究-3-末梢血リンパ球のADCC活性とcirculating immune complexの関連性

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The presence of soluble immune complex (IC) in the sera from patients with chronic liver diseases was examined by Platelet aggregation method and immunofluorescence method using neutrophils. Furthermore, relationship between the presence of IC and ADCC activity of peripheral blood lymphocytes was investigated.<BR>The results of these two methods for IC were almost the same. The frequency of IC was high in patients with primary biliary cirrhosis (75.0%) and hepatic cirrhosis (46.7%). It was higher in HBsAg negative cases of chronic liver disease than in HBsAg positive one, though the difference was stastically not significant.<BR>Singificant correlation between the presence of IC and reductio nof ADCC activity of peripheral blood lymphocytes or inhibition of ADCC by heat-aggregated IgG as a model of IC could not be recognized. Blockage of Fc receptors of peripheral blood K cells could not be attributable to these phenomena. It is likely that number of peripheral blood K cells was decreased or the functions of these cells were abnormal.
社団法人日本肝臓学会の論文