肝の色素移送に関する研究-2-D-galactosamineによる黄疸の発生機序,特にY蛋白の意義

概要

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This study was carried out for the purpos of clarifying the mechanism of transient hyperbilirubinemia caused by D-galactosamine (abbreviated as Gal) in rats. After 12 hours of an administration of Gal, serum transaminase and serum bilirubin (indirect type dominat) level were elevated slightly. In this stage, the concentration hepatic Y and Z proteins, and the rate of hepatic uptake of bilirubin-H3 were decreased, whereas hepatic UDPGT activity was not affected. Although the reduction of Y protein was seen earlier than the appearance of hyperbilirubinemia, the reduction of hepatic uptake of bilirubin-H3 was coincided with the development of hyperbilirubinemia. The hyperbilirubinemia and reduction of Y protein caused by Gal was protected with the pretreatment of phenobarbital or 3-methylcholanthrene. The results suggest that the transient hyperbilirubinemia caused by Gal was initiated by the disturbed function of the hepatic plasma membrane rather than by the decreased Y protein which bind bilirubin preferably, because some authors pointed out the injury of hepatic plasma membrane as a primary lesion which was induced by Gal.
社団法人日本肝臓学会の論文