肝の色素移送に関する研究-1-肝排泄能の促進をもたらす薬剤のYおよびZ蛋白に及ぼす影響

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概要

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• Influences of some drugs on both Y and Z proteins of the rat liver were examined by means of Sephadex G-75 column chromatography. Both proteins were confirmed by means of SDS-polyacrylamide gel electrophoresis. The drugs examined those enable to increase the hepatic excretion of BSP or may improve BSP retention test in the patient with chronic liver disease. <BR>Either sod. phenobarbiturate or polyen phosphatidylcholine increased the amount of Y protein significantly, and liver hydrolysate tended to increase it slightly. None of sod. hippurate, sod. salicylate and, sod. dehydrocholate affected on the amount of Y protein. None of these drugs affected on the amount of Z protein. An administration of large dose ofprednisolone, however, decreased amount of Y and Z proteins. The results suggest that an increase of biliary excretion of BSP dose not always depend on an increased amount of Y protein.

• 社団法人 日本肝臓学会の論文

著者

• 岡 富子

  山口大学医学部第1内科教室

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• 肝の色素移送に関する研究-1-肝排泄能の促進をもたらす薬剤のYおよびZ蛋白に及ぼす影響

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