Spur Cell Anemiaを来たし肝不全で死亡したアルコ-ル多飲者の1剖検例

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A 49 year-old male with severe hepatic failure and hemolytic anemia associated with striking acanthocytosis is described. For about 30 years he had a heavy alcohol intake. Physical examination revealed intense jaundice, ascites, splenomegaly and hemolytic anemia with spur-shaped red blood cells. The peculiar spur cells of this disorder are so named because of their "burr", "spiculated" morphology. <BR>Hemolytic anemia with "alcoholic" cirrhosis of the liver was diagnosed clinically. Severe hemolytic anemia persisted for about 4 months despite therapy with steroid hormone and the patient lapsed into hepatic coma and died. <BR>The cause of the spur cell formation is unknown. However it is considered likely that spur cell formation and hemolysis may be due to some factors in the patient's plasma. <BR>The pathological specimen of the liver showed micronodular cirrhosis (precirrhotic stage) with cholestasis and no fatty infiltration.
社団法人日本肝臓学会の論文