STUDIES ON PLASMIN AND FIBRINOGEN BY NEW METHOD WITH ε-AMINO CAPROIC ACID

概要

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1) Whole plasmin level in the plasma with all plasminogen activated by streptokinase was determined by measuring minimum effective dose of ε-ACA necessary to inhibit fibrinolysis.2) Twenty five mg was determined to be M.E.D. of ε-ACA necessary to inhibit whole plasmin activity in 100 ml of plasma in normal individuals. No difference between sexes was observed.3) The material must be examined on the day it is collected because an elevation of whole plasmin activity due to unknown cause was noted in the stored plasma.4) The effect of ε-ACA in the plasma was immediate and sure but short acting when given intravenously, on the other hand when orally given the effect was slow but long acting (more than 3 hours).5) The fibrinogen level decrease following administration of ε-ACA, although an increase of fibrinogen level along with decreased plasmin activity was theoretically expected.This rather puzzling, unexpected phenomenon may indicate some dynamic and complicated relationship among plasmin, antiplasmin and fibrinogen, which is of great interest and awaits further investigation.
The Keio Journal of Medicineの論文