EFFECT OF EPSILON-AMINOCAPROIC ACID AS AN ANTIFIBRINOLYTIC AGENT ON ARTERIAL LESIONS IN HYPERTENSIVE RATS WITH SURGICALLY CONSTRICTED RENAL ARTERIES

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1. Hypertensive rats with surgically constricted renal arteries were sub-cutaneously given 0.5 cc of isotonic saline solution containing 1 M epsilon-aminocaproic acid (ε-ACA; an antifibrinolytic agent) daily for 7 weeks, and it was found that the development of fibrinoid degeneration in arterial wall was considerably inhibited.2. In the ε-ACA-administered group, though the arterial intima occasionally showed severe fibrinoid degeneration, the adventitia of the arteries showed only slight cellular reaction and conspicuous fibrosis and cicatrization. Further in this group there was sometimes intimal thickening with proliferating fibroblasts and smooth muscle cells and deposited fibrinoid substance. In short, ε-ACA demon-strated an accelerating effect on the healing of arterial lesions in hypertensive rats.3. The administration of ε-ACA remarkably depressed plasmin activity of hypertensive rats, but did not exert evident effect on blood pressure. It is consequently assumed that the inhibition of the development of arterial lesions and the acceleration of those healing by the administration of ε-ACA would be ascribed to its depressive effect on the fibrinolytic activity of blood plasma (the plasmin activity), which was considered to be one of the causes of the increased vascular permeability leading to the development of the arterial lesions.
The Keio Journal of Medicineの論文