MATHEMATICAL DERIVATION OF THE BIOLOGICAL HALF-TIME OF CADMIUM IN HUMAN ORGANS BASED ON THE ACCUMULATION OF THE METAL IN THE ORGANS
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概要
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Although biological half-times of metals in an organ or the total body have been calculated in animal experiments in which a metal is administered and the reduction of the metal in the organ or total body measured, the present study attempts to estimate biological half-times of cadmium in the organs and total body of humans by the observed accumulation of cadmium according to age. In this study the biological half-time of cadmium in the organs, par- ticularly the kidney, and in the total body, were estimated to be much longer than results obtained from animal experiments. However, biological half-times estimated in this study vary greatly according to the amount of daily exposure to cadmium, sex, age, and certain other factors. The validity of the method used in this study needs further verification.
著者
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Seki Yukio
School Of Allied Health Sciences Kitasato University
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TSUCHIYA KENZABURO
School of Medicine, Keio University
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SUGITA MINORU
School of Medicine, Keio University
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