Clinical study on the psychotropic effects of caerulein. An open clinical trial in chronic schizophrenic patients.:AN OPEN CLINICAL TRIAL IN CHRONIC SCHIZOPHRENIC PATIENTS

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概要

• 論文の詳細を見る

• An open clinical trial of caerulein diethylamine, a cholecystokinin analogue, was performed in a total of 58 chronic schizophrenic patients maintained on drugs such as antipsychotic agents without dosage modification. The neuro-peptide medication by intramuscular route produced a clinical improvement in 20 cases and was eventually assessed to have been of therapeutic value in 23 cases. Clinical responses to the medication observed in the present series in-cluded: subjective changes in mood mostly to become feeling "fine" or "re-freshed in the head", improvement in contact, increased spontaneity and objective behavioral changes such as restlessness and excitement. These features of clinical responses observed in respect of mental condition seem to indicate that the drug affects emotion and exerts an analeptic effect as its principal clinical effects. The clinical effects were remarkably long sustained for 1-2 weeks after a single i.m. dose in most responders. Feeling of facial warmth and lassitude as well as symptoms of the gastrointestinal system were encountered as attendant symptoms in 6 cases.

• The Keio Journal of Medicineの論文

著者

• Tateyama Masato

  Department Of Chemical Energy And Environmental Engineering Kansai University

• Yagi Gohei

  Department Of Neuropsychiatry Keio University School Of Medicine

• Itoh Hitoshi

  Department Of Pathology School Of Medicine Tokai University

• Fujii Yasuo

  Department Of Applied Physics Faculty Of Engineering Osaka City University

• TANOUE SATORU

  Department of Neuropsychiatry, School of Medicine, Keio University

• KAMISADA MAMORU

  Department of Neuropsychiatry, School of Medicine, Keio University

• TAKAMIYA MAKI

  Department of Neuropsychiatry, School of Medicine, Keio University

• NAKAJIMA SEIICHIRO

  Department of Neuropsychiatry, School of Medicine, Keio University

• TATEYAMA MASATO

  Department of Neuropsychiatry, School of Medicine, Keio University

• FUJII YASUO

  Department of Neuropsychiatry, School of Medicine, Keio University

• ITOH Hitoshi

  Department of Nuclear Engineering, Kyushu University

• ITOH HITOSHI

  Department of Neuropsychiatry, School of Medicine, Keio University

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