スルフイソゾ-ル・トリメトプリム合剤のブリとウナギへの応用

概要

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In vitro and in vivo activities of a potentiated sulfonamide, sulfisozole/trimethoprim (3SI/TMP), against pathogens of yellowtail (Pasteurella piscicida, Vibrio anguillarum, Streptococcus sp.) and those of eel (Aeromonas hydrophila, Edwardsiella tarda) were determined. In vitro results showed that four bacteria except Streptococcus sp. had higher sensitivity to 3SI/TMP than to either of its components. MICs of 3SI/TMP (5: 1) were comparable to chloramphenicol.<BR>In vivo efficacy trials in yellowtail and eel, experimentally infected with P. piscicida, V. anguillarum, A. hydrophila or E.. tarda, indicated that 3SI/TMP (5: 1) was fairly active in oral administration. Activity of the combination drug seemed to be superior to oxytetracycline, but inferior to chloramphenicol.<BR>Tissue levels in yellowtail of 3SI and TMP were assayed after a single oral administration of 3SI/TMP (5: 1). 3SI appeared comparatively high in blood and kidney, while TMP high in kidney but not so in blood. Both 3SI and TMP were found to have the peak of tissue concentration at 3 or 6 hours post medication, excepting that the highest kidney level of TMP was observed at 12 or 18 hours.<BR>Elimination of TMP from tissues of yellowtail and eel administered orally with 3SI/TMP for 7 consecutive days were examined by microbiological assay. Residues of TMP could be detected in their kidneys for a long time.
日本魚病学会の論文