Inner Ear Autoantibodies in Patients with Sensorineural Hearing Loss

概要

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Using the western blotting technique, we examined the serum of patients with sensorineural hearing loss or vertigo for the presence of inner ear autoantibodies. The SDS soluble extract was prepared as the inner ear antigen from bovine inner ear tissues.<BR>About 70% of patients had inner ear specific autoantibodies which reacted with 32kD (8.1%), 33-35kD (14.9%), 42kD (14.9%) and 68kD (9.4%) determinants.<BR>In some patients sensorineural hearing loss may result from autoimmnue reactions directed against proteins derived from the inner ear. The inner ear specific autoantibodies may also enable us to diagnose autoimmune-mediated inner ear disorders and to treat these patients more effectively. It is necessary to purify the inner ear specific antigens for exact diagonosis of inner ear disorders.
日本めまい平衡医学会の論文