Detection of antibodies against crude cell walls of streptococcal strains in Behcet's disease and chronic recurrent aphthosis, and identification of antigen reacting to the antibody.

概要

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Serum anti-streptococcal antibodies were examined by the enzyme-linked immunosorbent assay. Levels of IgG and IgA antibodies in sera of patients with Behçet's disease against crude cell walls of Streptococcus salivarius (strain HHT) were significantly higher than those of healthy controls and patients with chronic recurrent aphthosis. IgA antibody titers of Behçet's patients against crude cell walls of S. pyogenes (M1, ATCC 19618) and S. sanguis (biotype A, serotype I, strain ST 3) were also significantly higher than those of healthy controls, but not higher than those of patients with chronic recurrent aphthosis.The correlation between anti-streptococcal antibody titers and clinical findings of Behret's disease was investigated, and it was revealed that most of Behçet's patients having had high titer of IgG antibody against S. salivarius belonged to the complete type of Behçet's disease. Sera from Behçet's patients with high titer of IgG antibody against S. salivarius reacted with a 48 kDa antigen of the crude cell wall by using Western blotting. However, this antigen also reacted with sera of patients with chronic recurrent aphthosis. Therefore, the antibody to the 48 kDa antigen was not considered as the pathognomonic finding in sera of patients with Behçet's disease.
日本臨床免疫学会の論文