Studies on FK 506, with special reference to clinical results in liver and kidney transplantation.
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概要
- 論文の詳細を見る
A new immunosuppressive agent FK 506 inhibits rejection of allografts at lower doses than Cyclosporine in experimental animals. On the other hand, FK 506 shows drug-toxicity including anorexia and vasculitis in the dog. Clinical studies at the University of Pittsburgh showed both immunosuppressive potency and side-effects of FK 506. Combination treatment with FK 506 and Cyclosporine or FK 506 and RS-61443 reduced minimum effective doses of both agents. In addition to enhancement of immunosuppressive potency by the combination treatment, vasculitis which was frequently observed at a low dose treatment with FK 506 became infrequent by an additional treatment with a low dose of Cyclosporine. The data presented here suggest usefulness of combination treatment with FK 506 and other immunosuppressive agents to enhance the immunosuppressive potency and to reduce sideeffects.
- 日本臨床免疫学会の論文
著者
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Ochiai Takenori
Department Of Academic Surgery (m9) Graduate School Of Medicine Chiba University
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Ochiai Takenori
Department of Surgery, School of Medicine, Chiba University
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- Studies on FK 506, with special reference to clinical results in liver and kidney transplantation.