Activated T-lympocytes and their subsets in drug fever.

概要

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Peripheral blood lymphocytes from 6 patients with typical drug fever due to antibiotics were studied by a 2-dimensional flow cytometry analyzer using monoclonal antibodies. The patients were diagnosed according to their clinical symptoms and the fever disappeared after discontinuation of the drug and no other cause for fever could be found. In all 6 patients the percentage of Leu-4+HLA-DR+ cells significantly increased (19.8±3.75%) at the onset of drug fever compared to that of the normal control group (5.8±2.15%) and acute bacterial infections group (7.0±2.59). The percentage of Leu-4+HLA-DR+ cells was on the decline after the discontinuation of the drug. Four out of 5 patients were completely normalized within two months after discontinuation of the drug. In the other patient with idiopathic interstitial pneumonitis, the percentage of Leu-4+HLA-DR+ cells decreased quickly but was not normalized. The higher percentage of Leu-4+HLA-DR+ cells were associated with an increase of Leu-3a+HLA-DR+ cells as well as Leu-2a+HLA-DR+ cells. More prominent increase was found in Leu-2a+HLA-DR+ cells in comparison to Leu-3a+HLA-DR+ cells.Interleukin-2 receptor was also measured using monoclonal antibodies at the same time, but no significant change was revealed.In conclusion, I consider the increased percentage of Leu-4+HLA-DR+ cells in total lymphocyte count to be useful method of diagnosing drug fever.
日本臨床免疫学会の論文