Class-specific Regulation of Anti-DNA Antibody Synthesis in (NZB×NZW) F1 Hybrid Mice
スポンサーリンク
概要
- 論文の詳細を見る
Investigations of regulatory helper and suppressor T cells in the in vitro anti-DNA antibody synthesis in NZB×NZW (B/W) F1 hybrid mice were initiated by the development of an in vitro system in which G 10-passed B cells from B/W F1 mice were cocultured with mitomycin C-treated T cells in the presence of concanavalin A and either presence or absence of lipopolysaccharide. It was revealed that each IgG and IgM anti-DNA antibody synthesis was under the regulation of separate L3T4+ helper and Ly2+ suppressor T cells. The function of these class-specific regulatory T cells was age dependent. While the helper effect of L3T4+ T cells on IgG antibody synthesis increased, the effect of L3T4+ T cells on IgM antibody production decreased in B/W F1 mice with aging. The IgG anti-DNA antibody production in the cocultures of L3T4+ T cells and B cells was suppressed by addition of Ly2+ T cells from young but not aged B/W F1 mice, whereas the production of IgM anti-DNA antibodies was suppressed by Ly2+ T cells from aged, but not young B/W F1 mice. It was also found that although IgM anti-DNA antibody producing B cells were already present in 2-mo-old mice, B cells producing IgG antibodies under the influence of L3T4+ T cells appeared in mice at 7 months of age. These data clearly indicate that separate class-specific regulatory T cells are involved in the production of each IgM and IgG anti-DNA antibodies and that the total serum level of the antibodies is reflected by both their age-associated changes and the generation of antibody-forming B cells in B/W F1 mice.
- 日本臨床免疫学会の論文
著者
関連論文
- IL-16とSLE-HIV-1 gp120との関連性において-
- Class-specific Regulation of Anti-DNA Antibody Synthesis in (NZB×NZW) F1 Hybrid Mice
- Soluble interleukin-2 receptor in sera of patients with systemic lupus erythematosus.
- レトロウイルスと全身性エリテマトーデス -HIV感染症との関連性を中心にして-