Cellular mechanism of nRNP-specific antibody synthesis by lymphocytes from patients with systemic lupus erythematosus
スポンサーリンク
概要
- 論文の詳細を見る
The cellular mechanism of anti-nRNP antibody synthesis in patients with systemic lupus erythematosus (SLE) was studied by nRNP-specific solid-phase radioimmunoassay.Spontaneous in vitro anti-nRNP antibody synthesis by lymphocytes from immunodiffusion determined anti-nRNP antibody positive, anti-Sm antibody negative (anti-nRNP positive) SLE patients were significantly higher than by those from the controls. In addition, similar amounts of anti-nRNP antibody were synthesized spontaneously in both active and inactive stage. The reconstitution experiments revealed that B cells and T cells from anti-nRNP positive SLE must cooperate to synthesize anti-nRNP antibody whether with nRNP stimulation or not. Accordingly, B cells and T cells may be activated in vivo due to unknown causes, and anti-nRNP antibody synthesis in response to nRNP was T-cell dependent.T8 cells from anti-nRNP positive SLE patients could suppress anti-nRNP antibody synthesis by autologous B cells, and in correlation with amounts of anti-nRNP antibody synthesized by their whole lymphocytes, their T4 cells could enhance anti-nRNP antibody synthesis by autologous B cells in response to nRNP. These results indicate that elevated anti-nRNP antibody synthesis in response to nRNP in patient with anti-nRNP positive SLE is due to the abnormality of T4 cells, and hyperactivity of nRNP reactive T4 cells may, in part, be responsible for deficient regulation of anti-nRNP antibody synthesis. These findings may lend further insight into understanding of various immunoregulatory defects in SLE.
- 日本臨床免疫学会の論文
著者
関連論文
- Study on DNA-specific suppressor T cell dysfunction in patients with systemic lupus erythematosus (SLE)
- Cellular mechanism of nRNP-specific antibody synthesis by lymphocytes from patients with systemic lupus erythematosus