Prevention of Postoperative Depression of Cellular Immunity by Preoperative Immunopotentiator Treatment in Gastric Cancer Patients

概要

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In cancer patients, surgical intervention has been reported to depress cellular immune competence in the early postoperative phase, thereby enhancing the proliferation of cancer cells scattered during surgery or the growth of residual cancer.Immunopotentiators such as PSK, Levamisole and Lentinan were administered to gastric cancer patients one or two weeks prior to surgery to prevent depression of postoperative cellular immunity.PSK was administered 3g/day perorally for seven consecutive days one week before surgery, Levamisole was also administered 150 mg/day perorally for three consecutive days one or two weeks before surgery and Lentinan was injected intravenously 0.5, 1 or 5mg twice a week one or two weeks before surgery.Numbers of leucocytes and lymphocytes were counted before and one week after immunopotentiator administration. Phytohemagglutinin (PHA) and Purified Protein Derivative (PPD) skin tests and PHA-induced lymphocyte transformation rate were examined before and one or two weeks after immunopotentiator treatment and one or two weeks after surgery.These immunological parameters showed preoperative immunopotentiator administration could prevent the depression of cellular immunity in the postoperative early phase.