Suppressor function of patients with systemic lupus erythematosus:I. Suppressor cells are generated normally in SLE by preculturing with or without Concanavalin A

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概要

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• Peripheral mononuclear cells from patients with systemic lupus erythematosus (SLE), when incubated for 48 hr with or without concanavalin A (ConA), were found to be capable of inhibiting the pokeweed mitogen (PWM)-induced polyclonal immunoglobulin (Ig) secretion by cells from normal individuals. Furthermore, these suppressor cells did not significantly affect on the Ig secretion by autologous B cells from patients with SLE. These results suggest that defective suppressive activity in patients with SLE is not at the T cell level, but, most likely, due to the defect of B cells in recognizing process of the suppressive information from suppressor T cells, caused by in vivo polyclonal B cell activation.

著者

• 矢野 啓介

  岡山大学第三内科

• 大藤 眞

  岡山大学第三内科

• 浅野 太郎

  岡山大学第3内科

• 中村 善一

  岡山大学第3内科

• 矢野 啓介

  岡山大学第3内科

• 大藤 眞

  岡山大学第3内科

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