Quantitative Measurement and Clinical Analysis of the Serum Levels of Immunosuppressive Acidic Protein (IAP) in Patients with Various Diseases

概要

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Serum levels of immunosuppressive acidic protein (IAP) of various diseases were measured by single radial immunodiffusion method. 2 to 10 times higher levels than normal values (394μg/ml) were found in patients with various cancers, SLE, scleroderma, cryptogenic pulmonary fibrosis, chronic bronchitis, pulmonary tuberculosis, pneumonia and bronchial asthma at these exacerbation or active stages. There were good correlations between IAP levels and blood sedimentation rate, α2-globulin values (p<0.001). The higher IAP levels of patients with cancer than 2, 000μg/ml were reflected the decreased ability of hypersensitivity to PPD or DNCB and poorer prognosis. It is suggested that serum IAP levels could be one of good indicators for evaluating the immunological activities of patients with various diseases.
日本臨床免疫学会の論文