Effect of streptococcal preparation, OK-432 on cultured spontaneous cell mediated cytotoxicity (CSCMC) and Ig production in vitro

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The effect of the steptoccocal preparation OK-432 on the in vitro immune responses by the human periperal blood lymphocytes was studied.The results obtained were as follows.1) OK-432 did not enhance natural killer (NK) cell activity.2) OK-432 enhanced cultured spontaneous cell mediated cytotoxicity (CSCMC). The most enhancing effect is at a concentration of around 10-3 KE/ml and is recognized as statistically significant at the cultured duration of 3, 5 and 7 days.The activity of CSCMC was most remarkable in the cell fraction which was not adherent to nylon wool and not rosetted with En.However, some of En-rosette-forming cells also had a little activity.3) OK-432 induced much more Ig production by B cell than did PWM.4) OK-432 stimulated DNA synthesis of lymphocytes.
日本臨床免疫学会の論文