Evaluation of serum immunosuppressive acidic protein (IAP) in patients with malignant disease

概要

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IAP is one of serum immunosuppressive factors in patients with malignant disease. We evaluated correlation between serum IAP values and other immunological parameters and histopathological findings in patients with malignant disease, especially gastric cancer and lung cancer.IAP values showed negative correlation with PPD and SU-PS skin tests in patients with gastric cancer and correlated with alpha 1-and alpha 2-globlin in patients with gastric cancer and lung cancer.IAP values also increased mostly in accordance with advances of the disease in patients with gastric cancer and lung cancer. In patients with gastric cancer, IAP values correlated with size of the tumor and showed significant difference between group with lymphnode metastasis and those without metastasis.These results suggested that IAP was useful to evaluate immunological state and advance of the disease in patients with malignant disease.However, IAP is not specific for malignant disease, since it is also closely related to inflammation.
日本臨床免疫学会の論文