Systemic Lupus Erythematosusにおける多核白血球CRl-赤血球CRlとの関連性について-

概要

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The defective C3b receptor (CRl) activity on erythrocytes is frequently seen in systemic lupus erythematosus (SLE) and leukemia. Defective CRl activity on erythrocytes in SLE is thought to be inherited as an autosomal codominant manner. CRl exsists on cell types other than erythrocytes, including neutrophils, eosionphils, monocytes, macrophages, B and some T lymphocytes, mast cells, and glomerular podocytes. The relationship of the expression of erythrocytes with other cell types is unclear. In this study we investigated the relationship of CRl activity between erythrocytes and polymorphonuclear leukocytes (PMN).The CRl activity on erythrocytes was measured by immune adherence hemagglutination (IAHA) using aggregated human IgG sensitized erythrocytes and guinea pig complement. Patients with SLE were grouped into two, group 1, those who possess CRI activity on erythrocytes, and group 2, those who showed defective CRl activity on erythrocytes.The activity of CRl on PMN was studied by; 1) rosette formation of PMN by EA (IgM) C3b, and 2) inhibition test of IAHA using EA (IgM) C3b lysate by PMN.Compared with healthy controls, SLE patients revealed significantly decreased rosette formation.