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概要

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• The percentages of the peripheral blood lymphocytes from 156 healthy individuals at different ages (20_??_98 yr olds) of both sexes and 11 patients with Werner's syndrome (premature aging syndrome) were studied by the use of monoclonal antibodies and two-dimensional flowcytometry. Pan-T monoclonal antibodies positive cells (Leu-1+ or Leu-4+) were decreased with age, which was attributable to a relative decrease in the Leu-2a+suppressor/cytotoxic T cells, more precisely in the Leu-2a+ Leu-15- cytotoxic T cells. In contrast to the cytotoxic T cells, Leu-3a+ Leu-8- helper T cells and Leu-4+ HLA-DR+ activated T cells were increased in proportion with age in the healthy controls. These age-related changes of the lymphocyte subpopulations were also observed in some patientswith Werner's syndrome.

• 日本臨床免疫学会の論文

著者

• 後藤 眞

  東京大学物療内科

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