Adrenergic Regulation of Prostaglandin Biosynthesis in Cultured Rabbit Gastric Epithelial Cells
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概要
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Adrenergic regulation of prostaglandin (PG) biosynthesis was investigated in 1-<SUP>14</SUP>C-arachidonic acid-prelabeled cultured rabbit gastric epithelial cells (RGECs). RGECs expressed adrenergic α<SUB>1</SUB>-and β-receptors and muscarinic receptors. Norepinephrine facilitated the synthesis of PGs I<SUB>2</SUB> (determined as the stable metabolite 6-keto PGF<SUB>1α</SUB>) and E<SUB>2</SUB> and hydroxyfatty acids, while epinephrine facilitated the synthesis of PGI<SUB>2</SUB> and hydroxyfatty acids, but not PGE<SUB>2</SUB>. However, isoproterenol did not affect PG biosynthesis. The effects of norepinephrine and epinephrine on PG biosynthesis were markedly suppressed by the non-selective α-blocker phentolamine and/or the selective α<SUB>1</SUB>-blocker prazosin. In combination with epinephrine, the selective α<SUB>2</SUB>-blocker yohimbine or the β-blocker propranolol facilitated PGE<SUB>2</SUB> synthesis. Acetylcholine did not affect PG biosynthesis. These results indicate that norepinephrine and epinephrine act on PG biosynthesis as adrenergic agonists in these cultured RGECs and that an α<SUB>1</SUB>-receptor couples PGI<SUB>2</SUB> and PGE<SUB>2</SUB> synthesis.
著者
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Ueda Fusao
Research Laboratories Nippon Shinyaku Co. Ltd.
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Kimura Kiyoshi
Research Labolatories Nippon Shinyaku CO. Ltd.
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Taniguchi Norihisa
Research Laboratories Of Nippon Shin-yaku Co. Ltd.
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KIMURA KIYOSHI
Research Laboratories, Nippon Shinyaku Co., Ltd.
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Taniguchi Norihisa
Research Laboratories, Nippon Shinyaku Co., Ltd.
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Ideguchi Kyoichi
Research Laboratories, Nippon Shinyaku Co., Ltd.
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