Synthesis and Antihypertensive Activities of 1,4-Dihydropyridine-5-phosphonate Derivatives. I(Medeicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
A series of phosphonate derivatives, designed as analogues of 1,4-dihydropyridine-3,5-dicarboxylates in which a phosphonate group was introduced instead of the carboxylate group at the 5-position, was synthesized, and their antihypertensive activities were examined. Among the compounds examined, 5-diallyloxyphosphinyl-1,4-dihydropyridine-3-carboxylates were most effective in lowering the blood pressure in normotensive rats and spontaneously hypertensive rats (SHR). The phosphonate derivatives are considered to be close analogues of the carboxylate derivatives. The structure-activity relationships are discussed.
- 公益社団法人日本薬学会の論文
- 1987-09-25
著者
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Kimura Kiyoshi
Research Labolatories Nippon Shinyaku CO. Ltd.
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Tada S
Research Laboratories Nippon Shinyaku Co. Ltd.
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Kimura K
Research Laboratories Nippon Shinyaku Co. Ltd.
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Kise Masahiro
Research Laboratories Nippon Shinyaku Co. Ltd.
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MORITA IWAO
Research Laboratories, Nippon Shinyaku Co. Ltd.
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TADA SHIN-ICHI
Research Laboratories, Nippon Shinyaku Co. Ltd.
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KUNIMOTO KATSUTOSHI
Research Laboratories, Nippon Shinyaku Co. Ltd.
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TSUDA MASAMI
Research Laboratories, Nippon Shinyaku Co. Ltd.
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Morita Iwao
Research Laboratories Nippon Shinyaku Co. Ltd.
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Tsuda Masami
Research Laboratories Nippon Shinyaku Co. Ltd.
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Kunimoto K
Research Laboratories Nippon Shinyaku Co. Ltd.
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