The Cytosolic Acidification in Rat Parotid Cells Is Associated with an Increase in Cytosolic Ca2+ Concentrtion.
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概要
- 論文の詳細を見る
A transient decrease in cytosolic pH ([pH]<SUB>i</SUB>)in rat parotid cells was evoked by the addition of carbachol (CCh), phenylephrine, or substance P, whereas isoproterenol and dibutyryl cyclic AMP had little or no effect on [pH]<SUB>i</SUB>. The decrease in [pH]<SUB>i</SUB> induced by the Ca<SUP>2+</SUP>-mobilizing agonists was also observed in Ca<SUP>2+</SUP>-free medium, but not when the intracellular Ca<SUP>2+</SUP> stores were previously depleted. lonomycin and thapsigargin elicited a decrease in [pH]<SUB>i</SUB> with an increase in cytosolic Ca<SUP>2+</SUP> concentration ([Ca<SUP>2+</SUP>]<SUB>i</SUB>). The protein kinase C activator and inhibitor had no effect on the agonist-induced decrease in [pH]<SUB>i</SIB>. These results suggest that the cytosolic acidification is associated with an increase in [Ca<SUP>2+</SUP>]<SUB>i</SUB>.
- 公益社団法人 日本薬理学会の論文
著者
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Tanimura Akihiko
Department Of Dental Pharmacology School Of Dentistry Health Sciences University Of Hokkaido
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Tojyo Yosuke
Department Of Dental Pharmacology School Of Dentistry Healty Sciences University Of Hokkaido
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Matsumoto Yoshito
Department Of Dental Pharmacology School Of Dentistry Healty Sciences University Of Hokkaido
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Tojyo Yosuke
Department of Dental Pharmacology, School of Dentistry, Higashi Nippon Gakuen University
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