EFFECTS OF DIMERCAPROL OR THIOCTIC ACID ON THE DISTRIBUTION AND EXCRETION OF Na_3^<74>AsO_3 INJECTED SUBCUTANEOUSLY IN RATS

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This report dealt with the effects of dimercaprol (BAL) and thiotic acid (TA), antidotes against arsenical, on the distribution and the excretion of ^<74>As in several organs of the rat. Each organ was removed and served for quantitative analysis of ^<74>As five days after subcutaneous injection of Na_3^<74>AsO3_ 5 μCi/100 g. Administration of BAL or TA was performed intraperitoneally with a single administration or five consecutive administrations for five days before animals were sacrificed. ^<74>As content in each organ of the rat decreased to a greater extent in the five consecutive administration group of BAL or TA than in the non-treated or single administration groups. Moreover, the excretion of ^<74>As in a digestive tract increased more remarkably in the five consecutive administration group than in the non-treated or single administration groups. There were no differences in the excretion or the content of ^<74>As in each organ between the single administration group and the non-treated group.
日本トキシコロジー学会の論文
1983-08-25