Inhibitory Effect of(4R)-Hexahydro-7,7-Dimethyl-6-Oxo-1,2,5-Dithiazocine-4-Carboxylic Acid(SA3443), a Novel Cyclic disulfide, on the Production of TNF-Like Factor from Propionibacterium Acnes-Primed Rat Liver Macrophages/Kupffer Cells.

スポンサーリンク

概要

• 論文の詳細を見る

• The effect of (4<I>R</I>)-hexahydro-7, 7-dimethyl-6-oxo-1, 2, 5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on tumor necrosis factor (TNF)-like factor production from <I>Propionibacterium acnes</I> (P. acnes)-primed rat liver macrophages/Kupffer cells was investigated. A remarkable increase in TNF-like activity was detected in the culture supernatants of the liver macrophages/Kupffer cells from P. acnes-treated rats. At concentrations of 1 × 10<SUP>-6</SUP> to 1 × 10<SUP>-4</SUP> M, SA3443 significantly inhibited the production/release of TNF-like factor from these P. acnes-primed/activated liver macrophages/Kupffer cells.

著者

• Mita Shiro

  Central Research Laboratories Santen Pharmaceutical Co. Ltd.

• Nakata Katsuhiko

  Central Research Laboratories, Santen Pharmaceutical Co., Ltd.

• Sasano Minoru

  Central Research Laboratories, Santen Pharmaceutical Co., Ltd.

関連論文

• Neurosteroids stimulate G protein-coupled sigma receptors in mouse brain synaptic membrane
• The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on chemically-induced acute liver injury.
• Inhibitory Effect of(4R)-Hexahydro-7,7-Dimethyl-6-Oxo-1,2,5-Dithiazocine-4-Carboxylic Acid(SA3443), a Novel Cyclic disulfide, on the Production of TNF-Like Factor from Propionibacterium Acnes-Primed Rat Liver Macrophages/Kupffer Cells.
• Hemodynamic effect and pharmacokinetics of semotiadil fumarate(SD-3211), a novel Ca channel blocker, in spontaneously hypertensive rats

スポンサーリンク