The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on chemically-induced acute liver injury.
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概要
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The effects of SA3443, a novel cyclic disulfide compound, on acute liver injuries induced by carbon tetrachloride (CCl<SUB>4</SUB>), D-galactosamine and DL-ethionine were studied in rats or mice. SA3443 (100-300 mg/kg, p.o.) significantly suppressed the increases of serum transaminase activity and liver triglyceride content in the CCl<SUB>4</SUB> or DL-ethionine-induced model. Furthermore, SA3443 (300 mg/kg, p.o.) clearly reduced the formation of hepatic lipid peroxide in CCl<SUB>4</SUB>-treated rats. These results indicate that SA3443 protects the liver against acute liver injury.
著者
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Mita Shiro
Central Research Laboratories Santen Pharmaceutical Co. Ltd.
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Nakata Katsuhiko
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
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Ishida Naruhiro
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
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Tanaka Mihoko
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
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Takase Kenji
Central Research Laboratories, Santen Pharmaceutical Co., Ltd.
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