Protective Effects of Antioxidants on Paraquat-Induced Acute Renal Failure in Mice.
スポンサーリンク
概要
- 論文の詳細を見る
The protective effects of antioxidants against elevated blood urea nitrogen (BUN) were studied in newly developed acute renal failure in mice induced by paraquat. The administration of paraquat caused marked azotemia accompanied by a decreased glomerular filtration rate. In contrast, elevated BUN was significantly reduced by the preadministration of either dimethylthiourea, deferoxamine or α-tocopherol. These data suggest that acute renal failure induced by paraquat is mainly related to the hydroxyl radicals produced via the iron-catalyzed Haber-Weiss reaction.
- 公益社団法人 日本薬理学会の論文
著者
-
Yagi Mikio
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd
-
Nagano Nobuo
Pharmaceutical Development Laboratories Kirin Brewery Co. Ltd.
-
Nishikori Koji
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
-
Yagi Mikio
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd.
関連論文
- Functional Proteins Involved in Regulation of Intracellular Ca^ for Drug Development : The Extracellular Calcium Receptor and an Innovative Medical Approach to Control Secondary Hyperparathyroidism by Calcimimetics
- Long-term observation of glomerulonephritis induced by multiple injections with anti-Thy-1 antibody in rats
- Transient expression of type I collagen in glomeruli with anti-Thy-1 antibody-induced mesangial proliferative lesions
- Pharmacological properties of the calcimimetic compound NPS R-568 in vitro and in vivo
- Antioxidant Activities of α-Tocopherol and Hydroxycarbazole against Lipid Peroxidation in Homogeneous Solution and in Liposomal Membranes
- An Investigation on Stability of Chitosan-Coated Dialdehyde Cellulose at Physiological pH Condition
- Characteristics of Lectin Staining Patterns Assessed by a Modified Sensitive Thermo-Method in Rat Livers with Heterologous Serum-Induced Fibrosis.
- Protective Effects of Antioxidants on Paraquat-Induced Acute Renal Failure in Mice.