Repeated Treatment with Levoprotiline, a Novel Antidepressant, Up-Regulates Histamine H1 Receptors and Phosphoinositide Hydrolysis Response In Vivo.

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概要

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• The effects of repeated administration of levoprotiline, a novel type of tetracyclic antide-pressant on histamine H<SUB>1</SUB>, muscarinic acetylcholine and α<SUB>1</SUB>-adrenergic receptors and the response of phosphoinositide hydrolysis (PI) stimulated by histamine in the cortex of the rat brain were investigated. Histamine H<SUB>1</SUB> receptors were up-regulated to 120% and PI response stimulated by histamine was enhanced to 160%-200% after repeated treatment with levoprotiline (20 mg/kg, i.p., once a day for 28 days) when compared to that of the saline-treated group. No significant alterations of muscarinic acetylcholine and α<SUB>1</SUB>-adrenergic receptors were observed. This demonstrates that the repeated treatment with levoprotiline has prominent action on the regulation of histamine H<SUB>1</SUB> receptors and PI response coupling to histamine H<SUB>1</SUB> receptors in vivo.

• 公益社団法人 日本薬理学会の論文

著者

• Inukai Toshiya

  Biological Research Laboratories, Pre-Clinical Research Department, Research & Development Sub-division, Pharmaceutical Division, Ciba-Geigy (Japan) Limited

• Noguchi Seiji

  Biological Research Laboratories, Pre-Clinical Research Department, Research & Development Sub-division, Pharmaceutical Division, Ciba-Geigy (Japan) Limited

関連論文

• Repeated Treatment with Levoprotiline, a Novel Antidepressant, Up-Regulates Histamine H1 Receptors and Phosphoinositide Hydrolysis Response In Vivo.
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