Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.

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概要

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• Carbamazepine (10 and 20 mg/kg, i.p., P<0.01 ; 40 mg/kg p.o., P<0.01), Li<SUB>2</SUB>CO<SUB>3</SUB> (200 mg/kg, i.p., P<0.01; 200 mg/kg, p.o., P<0.05), diazepam (0.5 mg/ kg, i.p., P<0.01) and haloperidol (0.5 mg/kg, i.p., P<0.01) significantly decreased the number of fighting episodes induced by footshock in mice. Picrotoxin (0.3 mg/kg, s.c.) and bicuculline (0.5 mg/kg, s.c.) antagonized the effect of carbamazepine or diazepam completely. Our present results suggest that the taming property of carbamazepine in the footshock model have some relation with the GABAergic mechanism.

• 公益社団法人 日本薬理学会の論文

著者

• Inukai Toshiya

  Biological Research Laboratories, Pre-Clinical Research Department, Research & Development Sub-division, Pharmaceutical Division, Ciba-Geigy (Japan) Limited

• NAKAO Kenzo

  Biological Research, Research and Development Department, Pharmaceutical Division

• HIGASHIO Takahiro

  Biological Research, Research and Development Department, Pharmaceutical Division

• INUKAI Toshiya

  Biological Research, Research and Development Department, Pharmaceutical Division

関連論文

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• Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.

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